A reliable and automated synthesis of 6-[18F]fluoro-L-DOPA and the clinical application on the imaging of congenital hyperinsulinism of infants

6-[18F]fluoro-L-DOPA is a radiotracer widely used in the diagnosis of range diseases, including neuro-oncology, endocrinology, and Parkinson’s disease. To meet rapidly growing clinical need for this radioactive compound, study reports an optimized radiosynthesis molecule, which proved to be highly reliable compatible with different types automated radiosynthesizers. Moreover, 6-[18F]fluoro-L-DOPA, PET/CT imaging total 23 patients has been conducted, further demonstrating as clinically valuable reagent diagnose congenital hyperinsulinism (CHI) infants non-invasive manner and, more importantly, localize exact lesion on pancreas.